Accepted Paper:

From discovery to distribution of sickle cell gene in India: a review  

Author:

Bhaskar Urade (University of Pune)

Paper short abstract:

The present paper is based on secondary sources published in various journals and books. The study of sickle cell anaemia can be used as useful genetic marker. The high magnitude of sickle cell gene has been located from South India followed by Central and Western with sporadic cases from Eastern India.

Paper long abstract:

Sickle haemoglobin is a structural variant of normal adult haemoglobin results from a single amino acid of beta globin molecule (β 6Glu→Val). Sickle cell is most common pathological haemoglobin variant in the world. The data includes from castes and communities, scheduled castes, scheduled tribes covering western, southern, central, northern and eastern India. In India study on sickle cell anaemia mostly confined on tribal groups and very few on other populations. In India, HbS gene ranges from 0 to 40 % among different Indian populations that includes castes, communities and tribes. Among Mahar HbS ranges from 0 to 24 % while that of sickle cell disease ranges from 0 to 6 %. In other caste groups it ranges from 0 to 9 % while among Brahmin and Muslim populations it ranges from 0 to 4.5 % and 0 to 3 % respectively. Sickle cell present in high frequency among the scheduled tribes as compared to other ethnic groups- castes, scheduled castes and communities. The high magnitude of sickle cell gene has been located from South India followed by Central, Western with sporadic cases from Eastern India.

Panel P057
Bio-cultural approach in human health study: retrospect and prospect