Paper Short Abstract

This research on research work presents a portfolio-based methodology designed to guide the thematic focus of a biomedical research call. By comparing research efforts and capacity with disease burden, the approach identifies funding gaps and supports evidence-based strategic decision-making.

Paper Abstract

Global challenges in health demand targeted research; hence, funders are increasingly deploying mission-oriented funding strategies. Assessing whether these instruments align with health and societal needs might not be straightforward, and a portfolio-level approach can help, rather than cherry-picking project evaluations. In this way, targeted and strategic funding can help shape the demand for biomedical research oriented to societal and health needs.

This work presents a methodology designed to shape the thematic focus of a biomedical research call, ensuring that research investments align with societal needs. By comparing research capacity with disease burden, this approach identifies funding gaps and provides a flexible, data-driven framework for strategic decision-making.

Using publicly available data and straightforward indicators, the methodology offers evidence-based insights to support prioritization in science policy. It highlights strengths and misalignments in research investment, enabling funding agencies and policymakers to optimize resource allocation. The methodology’s adaptability allows it to be tailored to different strategic priorities, while its visual component enhances accessibility, fostering discussion among diverse stakeholders.

Here we present an application of this approach in prioritizing research funding across five major disease groups, comparing research capacity and disease burden in Catalonia. The methodology proves particularly valuable when combined with participatory processes, SWOT analyses, refined definitions of research priorities, or prospective scenario analyses.

In conclusion, this methodology provides evidence-based insights to support policymakers in designing funding mechanisms that optimize resource allocation and maximize societal impact. This work contributes to advancing methodologies for evaluating the effectiveness of research funding strategies in addressing societal needs.