Short abstract

The Aligning Science Across Parkinson’s (ASAP) initiative supports a robust Open Science Policy and Compliance Workflow. Through this effort, between 60-84% of datasets, analysis scripts, protocols, and key lab materials from ASAP-funded studies are openly shared.

Long abstract

Sharing of research data, code, protocols, and lab materials remains limited and, in turn, undermines the cumulative nature of scientific discovery. The Aligning Science Across Parkinson’s (ASAP) initiative developed a thorough Open Science Policy and Compliance Workflow aimed to increase the deposition and unambiguous identification of data, code, protocols, and key lab materials (e.g., cell lines, antibodies) used and generated in the research we fund.

The policy requires grantees to post preprints, share a manuscript draft with ASAP staff, deposit all research outputs, and unambiguously identify all research inputs. The workflow is executed by an ASAP staff member who integrates automated and manual assessments to provide a grantee with systematic feedback outlining the actions required to align their manuscript draft with the ASAP Open Science Policy.

To facilitate this workflow, grantees share each manuscript alongside a Key Resource Table which lists persistent identifiers for the associated datasets, code, software, protocols, and key lab materials. When collated, these Key Resource Tables produce a near-comprehensive log of all the inputs and outputs from the research we fund.

Of 72 ASAP-funded articles published in 2024, between 60-84% of newly-generated datasets, analysis scripts, protocols, and key lab materials were shared. 97% of publications had an associated preprint. Preprints were posted a median of 3.5 days (IQR: -10 to 70) before manuscript submission, and 204 days (IQR: 118 to 314) before manuscript publication.

This talk will outline lessons learned and propose how funders, institutions, publishers, and researchers can align to accelerate scientific discovery.