Paper short abstract:

In this paper I am trying to highlight the history of the many indigenous communities living in different ecological zones in India and the high magnitude of sickle cell gene distribution in different parts of India.

Paper long abstract:

Sickle hemoglobin is a structural variant of normal adult haemoglobin results from a single amino acid of beta globin molecule (β 6Glu→Val). Sickle cell is most common pathological haemoglobin variant in the world. The data includes from castes and communities, Scheduled Castes, Scheduled Tribes covering western, southern, central, northern and eastern India. In India study on sickle cell anaemia mostly confined on tribal groups and very few on other populations. In India, HbS gene ranges from 0 to 40.00 percent among different Indian populations that includes castes, communities and tribes. Among Mahar HbS ranges from 0 to 24.00 percent while that of sickle cell disease ranges from 0 to 6.00 percent. In other caste groups it ranges from 0 to 9.00 percent while among Brahmin and Muslim populations it ranges from 0 to 4.50 percent and 0 to 3.00 percent respectively. Sickle cell present in high frequency among the scheduled tribes as compared to other ethnic groups- castes, scheduled castes and communities. The high magnitude of sickle cell gene has been located from South India followed by Central, Western with sporadic cases from Eastern India.