Using a single iv injection of 1 mg Evans blue dye/100 g body wt in Tribes(lambada), The contribution of fluid Phase endocytosis bile flow was estimated.In normal tribes,this pathway contributed 2-4% of the bie flow or 10- 20 ul/hr/100 g body weight.
Paper long abstract:
Using a single iv injection of 1 mg Evans blue dye/100 g body wt in Tribes(lambada), The contribution of fluid Phase endocytosis bile flow was estimated.In normal tribes,this pathway contributed 2-4% of the bie flow or 10- 20 ul/hr/100 g body weight. This contribution was not affected by cholestasis induced by taurolithocholic acid bile duct obstraction or by cholersis induced by dehydrocholic acid.It is concluded that fluid phase endocytosis does not significantly influence bile formation but, rather ,may be implecatied in the remodeling of liver cell plasma membranes.