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Short abstract:

The DNA Dialogues employs and evaluates the creative method of confrontational theater to engage underrepresented lay audiences on Human Germline Gene Editing, emphasizing inclusivity. Using qualitative research, we aim to uncover public values and needs to inform effective policy deliberation.

Long abstract:

Human Germline Gene Editing (HGGE), the altering of genetic information in human germ cells, has been made possible with the advent of CRISPR-cas9 systems. This technology has significant societal implications and therefore necessitates careful consideration of its desirability through societal engagement beyond scientific circles. In the Netherlands, The DNA-Dialogues employ the creative method of confrontational theater in collaboration with Stichting Confro to engage diverse audiences, including underrepresented groups, in dialogue. Stichting Confro specializes in theater on controversial topics, encouraging greater engagement with their audience through trust-building. This study evaluates the effectiveness of this approach in eliciting successful dialogue and exploring ethical norms surrounding HGGE. The first twelve dialogues were conducted in different settings within Rotterdam, including schools and community centers. We assessed dialogue success depending on pre-defined conditions and analyzed recorded dialogues thematically to identify emerging ethical themes. Preliminary results show the success of confrontational theater as it promotes a safe space for fruitful discussion. Still, it requires a lengthy build-up, and information provided on HGGE and consequently topic of the dialogue varied depending on the dialogue-facilitators. We identified diverse medical ethical themes (e.g. autonomy, non-maleficence), influenced by participants’ background (including education, religion, disability). This study shows that confrontational theater is a promising tool for public engagement on controversial topics yet may still benefit from methodological fine-tuning, with specific attention to the delicate balance between the creative ownership of the maker and goals of the researcher. Moreover, it emphasizes the importance of inclusivity in shaping policy decisions regarding HGGE.