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Africa is full of local initiatives with local change agents playing major roles in transformation processes. Important issues are how the skills and know-how of local change agents can be used for reaching scale, for example including large number of smallholder farmers or micro-entrepreneurs in agribusiness, and how successful local initiatives can expand to others areas or sub-sectors. A programme like 2SCALE has experienced many attempts of ‘partnering’ supporting the incubation of inclusive agribusiness and develops replication and alignment pathways to realize systemic change. What makes partnering process developmental? And what is the nature of institutional work underlying alliances conducive to reaching scale in inclusive agribusiness?